Research

New cut-off values for ferritin and soluble transferrin receptor for the assessment of iron deficiency in children in a high infection pressure area.
Phiri KS, Calis JC, Siyasiya A, Bates I, Brabin B, van Hensbroek MB.
J Clin Pathol. 2009 Dec;62(12):1103-6

The APPLe study: a randomized, community-based, placebo-controlled trial of azithromycin for the prevention of preterm birth, with meta-analysis.
van den Broek NR, White SA, Goodall M, Ntonya C, Kayira E, Kafulafula G, Neilson JP.
PLoS Med. 2009 Dec;6(12):e1000191. Epub 2009 Dec 1

Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype.
Kingsley RA, Msefula CL, Thomson NR, Kariuki S, Holt KE, Gordon MA, Harris D, Clarke L, Whitehead S, Sangal V, Marsh K, Achtman M, Molyneux ME, Cormican M, Parkhill J, MacLennan CA, Heyderman RS, Dougan G.

Genome Res. 2009 Dec;19(12):2279-87. Epub 2009 Nov 9

Biomass fuel use and indoor air pollution in homes in Malawi.
Fullerton DG, Semple S, Kalambo F, Suseno A, Malamba R, Henderson G, Ayres JG, Gordon SB.
Occup Environ Med. 2009 Nov;66(11):777-83. Epub 2009 Aug 10.

6.

T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease.
Mureithi MW, Finn A, Ota MO, Zhang Q, Davenport V, Mitchell TJ, Williams NA, Adegbola RA, Heyderman RS.

J Infect Dis. 2009 Sep 1;200(5):783-93

Low level genotypic chloroquine resistance near Malawi's northern border with Tanzania.
Bridges DJ, Molyneux M, Nkhoma S.

Trop Med Int Health. 2009 Sep;14(9):1093-6. Epub 2009 Jul 14

Bacterial vaginosis in female facility workers in north-western Tanzania: prevalence and risk factors.
Baisley K, Changalucha J, Weiss HA, Mugeye K, Everett D, Hambleton I, Hay P, Ross D, Tanton C, Chirwa T, Hayes R, Watson-Jones D.
Sex Transm Infect. 2009 Sep;85(5):370-5. Epub 2009 May 26

Nutritional status of Malawian adults on antiretroviral therapy 1 year after supplementary feeding in the first 3 months of therapy.
Ndekha M, van Oosterhout JJ, Saloojee H, Pettifor J, Manary M.
Trop Med Int Health. 2009 Sep;14(9):1059-63. Epub 2009 Jun 22

Dysregulation of coagulation in cerebral malaria.
Moxon CA, Heyderman RS, Wassmer SC.

Mol Biochem Parasitol. 2009 Aug;166(2):99-108. Epub 2009 Mar 26. Review

Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.
Bell DJ, Wootton D, Mukaka M, Montgomery J, Kayange N, Chimpeni P, Hughes DA, Molyneux ME, Ward SA, Winstanley PA, Lalloo DG.
Malar J. 2009 Aug 26;8:204

Improved method for assessing iron stores in the bone marrow.
Phiri KS, Calis JC, Kachala D, Borgstein E, Waluza J, Bates I, Brabin B, van Hensbroek MB.

J Clin Pathol. 2009 Aug;62(8):685-9

Diagnosis of antiretroviral therapy failure in Malawi: poor performance of clinical and immunological WHO criteria.
van Oosterhout JJ, Brown L, Weigel R, Kumwenda JJ, Mzinganjira D, Saukila N, Mhango B, Hartung T, Phiri S, Hosseinipour MC.

Trop Med Int Health. 2009 Aug;14(8):856-61. Epub 2009 Jun 22

The macrophage marches on its phagosome: dynamic assays of phagosome function.
Russell DG, Vanderven BC, Glennie S, Mwandumba H, Heyderman RS.
Nat Rev Immunol. 2009 Aug;9(8):594-600. Epub 2009 Jul 10

Use of an early warning score and ability to walk predicts mortality in medical patients admitted to hospitals in Tanzania.
Rylance J, Baker T, Mushi E, Mashaga D.

Trans R Soc Trop Med Hyg. 2009 Aug;103(8):790-4. Epub 2009 Jun 21

The diagnostic and prognostic accuracy of five markers of serious bacterial infection in Malawian children with signs of severe infection.
Carrol ED, Mankhambo LA, Jeffers G, Parker D, Guiver M, Newland P, Banda DL; IPD Study Group, Molyneux EM, Heyderman RS, Molyneux ME, Hart CA.

PLoS One. 2009 Aug 13;4(8):e6621

The value of the post-take ward round: are new working patterns compromising junior doctor education?
Chaponda M, Borra M, Beeching NJ, Almond DS, Williams PS, Hammond MA, Price VA, Tarry L, Taegtmeyer M.

Clin Med. 2009 Aug;9(4):323-6

The double burden of human resource and HIV crises: a case study of Malawi.
McCoy D, McPake B, Mwapasa V.

Hum Resour Health. 2008 Aug 12;6:16

Parasites bearing a single copy of the multi-drug resistance gene (pfmdr-1) with wild-type SNPs predominate amongst Plasmodium falciparum isolates from Malawi.
Nkhoma S, Nair S, Mukaka M, Molyneux ME, Ward SA, Anderson TJ.

Acta Trop. 2009 Jul;111(1):78-81. Epub 2009 Feb 4

Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes.
Fry AE, Ghansa A, Small KS, Palma A, Auburn S, Diakite M, Green A, Campino S, Teo YY, Clark TG, Jeffreys AE, Wilson J, Jallow M, Sisay-Joof F, Pinder M, Griffiths MJ, Peshu N, Williams TN, Newton CR, Marsh K, Molyneux ME, Taylor TE, Koram KA, Oduro AR, Rogers WO, Rockett KA, Sabeti PC, Kwiatkowski DP.

Hum Mol Genet. 2009 Jul 15;18(14):2683-92. Epub 2009 Apr 29

Malarial retinopathy and fluorescein angiography findings in a Malawian child with cerebral malaria.
Glover SJ, Maude RJ, Taylor TE, Molyneux ME, Beare NA.

Lancet Infect Dis. 2010 Jun;10(6):440

Interferon-gamma release assays do not identify more children with active tuberculosis than the tuberculin skin test.
Kampmann B, Whittaker E, Williams A, Walters S, Gordon A, Martinez-Alier N, Williams B, Crook AM, Hutton AM, Anderson ST.

Eur Respir J. 2009 Jun;33(6):1374-82. Epub 2009 Feb 5

Effect of recurrent invasive pneumococcal disease on serum anti-pneumolysin IgG titres in HIV infected adults.
Etuwewe OM, Swann N, Hollingshead S, Tolmie H, Zijlstra EE, Faragher B, French N, Gordon SB.

Vaccine. 2009 Jun 12;27(29):3881-4. Epub 2009 May 3

The public health approach to identify antiretroviral therapy failure: high-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapy.
Hosseinipour MC, van Oosterhout JJ, Weigel R, Phiri S, Kamwendo D, Parkin N, Fiscus SA, Nelson JA, Eron JJ, Kumwenda J.

AIDS. 2009 Jun 1;23(9):1127-34

Opsonic function of bronchoalveolar lavage IgG after pneumococcal vaccination in HIV-infected and uninfected adults.
Tam JC, Grant NL, Freire-Moran L, Tolmie H, French N, Gordon SB.
J Allergy Clin Immunol. 2009 Jun;123(6):1420-1. Epub 2009 May 7

Malaria and vitamin A deficiency in African children: a vicious circle?
Sanjoaquin MA, Molyneux ME.
Malar J. 2009 Jun 17;8:134. Review

Association between Gc genotype and susceptibility to TB is dependent on vitamin D status.
Martineau AR, Leandro AC, Anderson ST, Newton SM, Wilkinson KA, Nicol MP, Pienaar SM, Skolimowska KH, Rocha MA, Rolla VC, Levin M, Davidson RN, Bremner SA, Griffiths CJ, Eley BS, Bonecini-Almeida MG, Wilkinson RJ.

Eur Respir J. 2010 May;35(5):1106-12. Epub 2009 Sep 24

IgA1 antibodies specific for outer membrane protein PorA modulate the interaction between Neisseria meningitidis and the epithelium.
Horton RE, Vidarsson G, Virji M, Williams NA, Heyderman RS.

Microb Pathog. 2009 May;46(5):253-60. Epub 2009 Feb 5

Genome-wide and fine-resolution association analysis of malaria in West Africa.
Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, Somaskantharajah E, Whittaker P, Widden C, Donnelly P, Howie B, Marchini J, Morris A, Sanjoaquin M, Achidi EA, Agbenyega T, Allen A, Amodu O, Corran P, Djimde A, Dolo A, Doumbo OK, Drakeley C, Dunstan S, Evans J, Farrar J, Fernando D, Hien TT, Horstmann RD, Ibrahim M, Karunaweera N, Kokwaro G, Koram KA, Lemnge M, Makani J, Marsh K, Michon P, Modiano D, Molyneux ME, Mueller I, Parker M, Peshu N, Plowe CV, Puijalon O, Reeder J, Reyburn H, Riley EM, Sakuntabhai A, Singhasivanon P, Sirima S, Tall A, Taylor TE, Thera M, Troye-Blomberg M, Williams TN, Wilson M, Kwiatkowski DP; Wellcome Trust Case Control Consortium; Malaria Genomic Epidemiology Network.

Nat Genet. 2009 May 24. [Epub ahead of print]

Supplementary feeding with either ready-to-use fortified spread or corn-soy blend in wasted adults starting antiretroviral therapy in Malawi: randomised, investigator blinded, controlled trial.
Ndekha MJ, van Oosterhout JJ, Zijlstra EE, Manary M, Saloojee H, Manary MJ.
BMJ. 2009 May 22;338:b1867. doi: 10.1136/bmj.b1867

Neuroimaging findings in children with retinopathy-confirmed cerebral malaria.
Potchen MJ, Birbeck GL, Demarco JK, Kampondeni SD, Beare N, Molyneux ME, Taylor TE.
Eur J Radiol. 2010 Apr;74(1):262-8. Epub 2009 Apr 3

Suitability of simple human immunodeficiency virus rapid tests in clinical trials in community-based clinic settings.
Everett DB, Baisley K, Changalucha J, Vallely A, Watson-Jones D, Cook C, Knight L, Ross DA, Mugeye K, McCormack S, Lacey CJ, Jentsch U, Hayes RJ.

J Clin Microbiol. 2009 Apr;47(4):1058-62. Epub 2009 Feb 25

Impaired maintenance of naturally acquired T-cell memory to the meningococcus in patients with B-cell immunodeficiency.
Morales-Aza B, Glennie SJ, Garcez TP, Davenport V, Johnston SL, Williams NA, Heyderman RS.
Blood. 2009 Apr 30;113(18):4206-12. Epub 2009 Feb 6

Research capacity development in Malawi: Malcolm Molyneux's role.
Mwandumba HC.

Trans R Soc Trop Med Hyg. 2009 Apr;103 Suppl 1:S19-22. Epub 2009 Feb 20

Developing national treatment policy for falciparum malaria in Africa: Malawi experience.
Malenga G, Wirima J, Kazembe P, Nyasulu Y, Mbvundula M, Nyirenda C, Sungani F, Campbell C, Molyneux M, Bronzan R, Dodoli W, Ali D, Kabuluzi S.
Trans R Soc Trop Med Hyg. 2009 Apr;103 Suppl 1:S15-8. Epub 2009 Mar 13

TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression.
Campino S, Forton J, Auburn S, Fry A, Diakite M, Richardson A, Hull J, Jallow M, Sisay-Joof F, Pinder M, Molyneux ME, Taylor TE, Rockett K, Clark TG, Kwiatkowski DP.

Malar J. 2009 Mar 13;8:44

Domestic smoke exposure is associated with alveolar macrophage particulate load.
Fullerton DG, Jere K, Jambo K, Kulkarni NS, Zijlstra EE, Grigg J, French N, Molyneux ME, Gordon SB.

Trop Med Int Health. 2009 Mar;14(3):349-54

Nonradioactive heteroduplex tracking assay for the detection of minority-variant chloroquine-resistant Plasmodium falciparum in Madagascar.
Juliano JJ, Randrianarivelojosia M, Ramarosandratana B, Ariey F, Mwapasa V, Meshnick SR.

The outcome of non-typhoidal salmonella meningitis in Malawian children, 1997-2006.
Molyneux EM, Mankhambo LA, Phiri A, Graham SM, Forsyth H, Phiri A, Walsh AL, Wilson LK, Molyneux ME.

Ann Trop Paediatr. 2009 Mar;29(1):13-22

Relationship between human immunodeficiency virus type 1 coinfection, anemia, and levels and function of antibodies to variant surface antigens in pregnancy-associated malaria.
Jaworowski A, Fernandes LA, Yosaatmadja F, Feng G, Mwapasa V, Molyneux ME, Meshnick SR, Lewis J, Rogerson SJ.
Clin Vaccine Immunol. 2009 Mar;16(3):312-9. Epub 2009 Jan 7

Successful treatment of cytomegalovirus polyradiculopathy in a 9-year-old child with congenital human immunodeficiency virus infection.
Sohal A, Riordan A, Mallewa M, Solomon T, Kneen R.

J Child Neurol. 2009 Feb;24(2):215-8

Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.
Clark TG, Diakite M, Auburn S, Campino S, Fry AE, Green A, Richardson A, Small K, Teo YY, Wilson J, Jallow M, Sisay-Joof F, Pinder M, Griffiths MJ, Peshu N, Williams TN, Marsh K, Molyneux ME, Taylor TE, Rockett KA, Kwiatkowski DP.

J Infect Dis. 2009 Feb 15;199(4):569-75

The effects of hypoxia on the ERG in paediatric cerebral malaria.
Lochhead J, Movaffaghy A, Falsini B, Harding S, Riva C, Molyneux M.
Eye (Lond). 2010 Feb;24(2):259-64. Epub 2009 Jun 26

Absence of mucosal immunity in the human upper respiratory tract to the commensal bacteria Neisseria lactamica but not pathogenic Neisseria meningitidis during the peak age of nasopharyngeal carriage.
Vaughan AT, Gorringe A, Davenport V, Williams NA, Heyderman RS.

J Immunol. 2009 Feb 15;182(4):2231-40

Perfusion abnormalities in children with cerebral malaria and malarial retinopathy.
Beare NA, Harding SP, Taylor TE, Lewallen S, Molyneux ME.

J Infect Dis. 2009 Jan 15;199(2):263-71

Simple measures are as effective as invasive techniques in the diagnosis of pulmonary tuberculosis in Malawi.
Bell DJ, Dacombe R, Graham SM, Hicks A, Cohen D, Chikaonda T, French N, Molyneux ME, Zijlstra EE, Squire SB, Gordon SB.

Int J Tuberc Lung Dis. 2009 Jan;13(1):99-104

Prevalence distribution and risk factors for Schistosoma hematobium infection among school children in Blantyre, Malawi.
Kapito-Tembo AP, Mwapasa V, Meshnick SR, Samanyika Y, Banda D, Bowie C, Radke S.
PLoS Negl Trop Dis. 2009;3(1):e361. Epub 2009 Jan 20

Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three African populations.
Mangano VD, Clark TG, Auburn S, Campino S, Diakite M, Fry AE, Green A, Richardson A, Jallow M, Sisay-Joof F, Pinder M, Griffiths MJ, Newton C, Peshu N, Williams TN, Marsh K, Molyneux ME, Taylor TE, Modiano D, Kwiatkowski DP, Rockett KA.

PLoS One. 2009;4(1):e4206. Epub 2009 Jan 15

Risk factors for HIV incidence in women participating in an HSV suppressive treatment trial in Tanzania.
Watson-Jones D, Baisley K, Weiss HA, Tanton C, Changalucha J, Everett D, Chirwa T, Ross D, Clayton T, Hayes R.
AIDS. 2009 Jan 28;23(3):415-22

Retinal pathology of pediatric cerebral malaria in Malawi.
White VA, Lewallen S, Beare NA, Molyneux ME, Taylor TE.
PLoS One. 2009;4(1):e4317. Epub 2009 Jan 29