Print

Salmonella and Enteric Disease

    1. What is the burden of invasive Salmonella disease (urban and rural)?
    2. How is Salmonella transmitted in communities?
    3. How can we diagnose invasive Salmonella disease?
    4. What is optimal treatment for MDR invasive Salmonella?
    5. How can we prevent invasive Salmonella disease with vaccines or WSH?
  • MLW has been working on invasive Salmonella disease for 18 years. There have been sequential epidemics of both typhoid and invasive non-typhoidal Salmonella disease (iNTS) in Blantyre. Understanding of iNTS disease lags typhoid, with many large knowledge and tool gaps. We are investigating possibility of Chikwawa as an additional, rural Salmonella field site.
    1. What is the burden of invasive Salmonella disease (urban and rural)?
    2. How is Salmonella transmitted in communities?
    3. How can we diagnose invasive Salmonella disease?
    4. What is optimal treatment for MDR invasive Salmonella?
    5. How can we prevent invasive Salmonella disease with vaccines or WSH?
  • Lancet review on iNTS
    Recent first global burden of disease estimate of iNTS disease
    Recent pair of typhoid epidemic papers Nature Genetics / PLOS NTDs
    STRATAA strategic award towards typhoid vaccine implementation
    MRC Exptl Med Challenge for gut mucosal immunology
    BMGF knowledge gap grant for NTS diagnosis and transmission understanding