Emerging AMR

    1. What is the burden of antimicrobial resistance amongst the major bacterial pathogens in Malawi?
    2. What are the molecular mechanisms of antimicrobial resistance and what drives their emergence, maintenance in bacterial populations?
    3. Can we design interventions to control the emergence and spread of antimicrobial resistance?
  • Antimicrobial resistance is a major threat to human health globally. In Malawi, as in other resource poor countries, even the simplest antimicrobials remain a precious commodity. The aim of the AMR group is to gain a better understanding of the burden and factors that drive antimicrobial resistance in major bacterial pathogens, in order to design interventions to curb the emergence and spread of resistance in this setting.
    1. a) Define the burden of antimicrobial resistance in bacterial meningitis in Malawi.
      (b) Establish the aetiology and antimicrobial susceptibility profiles of surgical site infections in Malawi and other low-income settings.
    2. (a) Employ polyomics, competition experiments and modelling studies to predict how mass azithromycin administration programmes will drive the evolution of macrolide resistance in nasopharyngeal and enteric bacteria.
      (b) Establish the origin and molecular epidemiology of MRSA at QECH.
    3. (a) Define in the impact of PCV13 on the evolution of antimicrobial resistance in the pneumococcus.
      (b) Test the utility of the MinION handheld sequencing platform to rapidly characterise outbreaks of antimicrobial resistant bacteria.
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